Perturbation-Based Proteomic Correlation Profiling as a Target Deconvolution Methodology

Target deconvolution techniques in modern phenotypic profiling.

The past decade has seen rapid growth in the use of diverse compound libraries in classical phenotypic screens to identify modulators of a given process. The subsequent process of identifying the molecular targets of active hits, also called 'target deconvolution', is an essential step for understanding compound mechanism of action and for using the identified hits as tools for further dissecti...

affinity based target deconvolution of safranal

Serum Proteomic Profiling of Obsessive-Compulsive Disorder, Washing Subtype: A Preliminary Study

Introduction: Obsessive-Compulsive Disorder (OCD) is a disabling mental condition that its proteomic profiling is not yet investigated. Proteomics is a valuable tool to discover biomarker approaches. It can be helpful to detect protein expression changes in complex disorders such as OCD. Methods: Here, by the application of 2D gel electrophoresis (2DE), a pilot study of serum proteome profile ...

Mass spectrometry-based quantitative proteomic profiling.

Quantitative proteomics involves the identification and quantitation of protein components in various biological systems. Stable isotope labelling technology, by both metabolic and chemical methods, has been the most commonly used approach for global proteome-wide profiling. Recently, its capability has been extended from labelled pairs to multiple labels, allowing for the simultaneous quantifi...

CARP: Correlation Based Approach for Researcher Profiling

The accelerating progress in science with the active role of the communication media – mainly the web – make person in front of a difficult task, in finding appropriate information during a brief time. In a narrower context, many researches were created in the expertise retrieval domain, as an interesting and complicated task for the scientific community, in face of this huge amount of data sca...